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Founding of AVIGI

At AVIGI Therapeutics, we don’t just think outside the box—we dissolve it, analyze it, and reassemble it into something extraordinary. Our journey began with an unlikely hero: the disaccharide. These small sugar molecules may seem unassuming, but within their structure lies the blueprint for a groundbreaking heparanase inhibitor.

Why heparanase? This enzyme plays a key role in tissue remodeling, cancer metastasis, and inflammatory diseases, making it a prime target for therapeutic intervention. Inspired by nature’s own molecules, our team engineered a disaccharide-inspired inhibitor capable of selectively halting heparanase activity without disrupting healthy cellular processes.

This was innovation + biomimicry at its finest, with added scientific flair for problem-solving. By applying design principles to our understanding of molecular interactions and biology, we’ve turned a humble sugar into a precision therapeutic tool against some of the toughest diseases.

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Timeline

A snapshot of some of our public milestones

 2025

UNIIQ Boosts AVIGI

Our first commitment from the regional development fund of South-Holland, The Netherlands, funding our development efforts with a 350K EUR CLA.

 2024

Founding AVIGI Therapeutics

We incorporated the company under a new bold name: AVIGI Therapeutics B.V. Headquartered in Leiden, The Netherlands

2024

Unlock_  Incubator

Joined Unlock_ in Leiden to get incubated.

Winter 2023

Venture Challenge 

We participated in the Venture Challenge Winter Cohort of 2023, back then with the name Triangle Therapeutics

  Early startup story   Lifesciencesatwork.nl 
2023

ERC and NWO PoC Funding

European Research Council and NWO awarded the project funding

  Grant EU Website     Cordis.europa.eu 
2022

Discovery of our lead candidate

Composition of matter patent application submitted. Key innovations published. 

  Structural Mechanism     rcsb.org 


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