Scientist Translational Biology
LEIDEN,
Netherlands
We are seeking an exceptional scientist to join our team to advance our first-in-class covalent heparanase inhibitor program targeting multiple cancer indications. The ideal candidate will bridge preclinical insights with clinical development strategy, focusing on elucidating mechanism of action, identifying biomarkers, and translating complex cascade biology into meaningful clinical outcomes.
This position will play a crucial role in our mission to develop transformative therapies for patients with difficult-to-treat cancers.
Key Responsibilities
- Lead in vivo efficacy studies evaluating heparanase inhibitor combinations with standard-of-care therapies across multiple tumor models
- Design and interpret biomarker analyses to monitor cascade inhibition and develop patient selection strategies
- Collaborate with Tech Lead to optimize pharmacokinetic and pharmacodynamic properties of covalent inhibitors
- Develop translational strategies to effectively measure target engagement in preclinical models and clinical samples
- Analyze complex data sets connecting molecular changes to phenotypic outcomes in tumor and immune compartments
Must Haves
- PhD in Cancer Biology, Immunology, Pharmacology, or related field with 5+ years of industry experience
- Demonstrated expertise in extracellular matrix biology and tumor microenvironment
- Proven experience with in vivo oncology models, particularly those involving stromal-rich tumors
- Proficiency in multiplex analyses of tumor tissues (IHC, flow cytometry, RNA-seq)
- Excellent communication skills with ability to translate complex biology into development strategy
Nice to have
- Understanding of enzyme inhibitor pharmacology, particularly covalent inhibitor mechanisms
- Track record of successful cross-functional collaboration in drug development
- Familiarity with regulatory requirements for oncology drug development
- Understanding of the clinical landscape in targeted oncology
Why is this work relevant?
Our heparanase inhibitor program represents a first-in-class opportunity to target a master regulator of multiple cancer-promoting cascades. By developing a highly selective covalent inhibitor, we aim to disrupt tumor-stromal interactions, normalize the tumor microenvironment, and enhance the efficacy of current standard-of-care therapies. This position offers the opportunity to work at the cutting edge of cancer biology with a clear path to meaningful clinical impact.
Our Science
What We Offer
We offer a 12 months part-time role with the possibility to evolve the role to a full-time permanent position within our companies development team.
Perks
- Sufficient Salary
- Macbook Air that you can use privately
- Long Term Incentives (Equity Pool)
Personal Development
A blanc space to think and direct scientific studies without being in the lab.